Esomeprazole Gastro-resistant Tablets IP 40mg (PROSIUM) Taj Pharma Overview Introduction Prosium 40mg Tablet is a medicine which reduces the amount of acid produced in your stomach. If theyre more severe or dont go away, talk to your doctor or pharmacist. Esomeprazole sodium comes in an intravenous (IV) form, which is only given by a healthcare provider. Talk to your doctor about how to manage this condition if you develop it. Feeling sick (nausea) or being sick (vomiting). Esomeprazole may also be given to prevent gastric ulcer caused by infection with Helicobacter pylori (H. pylori), or by the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Healing of gastric ulcers associated with NSAID therapy. Get Best Price. Written by Cerner Multum. It works by blocking the proton pump in the stomachs cells. Healthline Media does not provide medical advice, diagnosis, or treatment. Your doctor may recommend a second course of treatment if you need additional healing time. It is not known if Esomeprazole passes into breast milk. The recommended dose is one Esomeprazole 40 mg tablet once a day for 4 weeks. Esomeprazole gastro-resistant tablets are not recommended for children less than 12 years old. new or worsening symptoms of lupus--joint pain, and a skin rash on your cheeks or arms that worsens in sunlight. You may need to decide whether to stop breastfeeding or stop taking this medication. 1. Examples of drugs that can cause interactions with esomeprazole magnesium are listed below. Fill the syringe with 25 ml of water and 5 ml of air and repeat step 5 if necessary to wash down any sediment left in the syringe. Esomeprazole or its major metabolites do not show any tendency to accumulate with once daily dosing. Its used for short-term treatment of the following: This drug comes with serious risks if you dont take it as prescribed. Both the R- and S-isomer of omeprazole have similar pharmacodynamic activity. Therefore, you should not take Esomeprazole if you are breast-feeding. Phenytoin (used in epilepsy). Product Name: Esomeprazole Gastro-resistant Tablets 40mg Brand Name: Generic Strength: 40mg Dosage Form: Tablets (Gastro-resistant) Route of Administration: Via Oral Route Packing: 10s, 30s, 100s, 500s Pack Insert/Leaflet: PIL (Patient Information Leaflet), SmPC (Summary Product Characteristics) Documents: COA, MOA, COPP, FSC, Stability Studies, For people with severe liver problems: The maximum dosage of esomeprazole magnesium shouldnt be more than 20 mg per day. Effects on your stomach or gut: diarrhoea, stomach pain, constipation, wind (flatulence). When starting or ending treatment with esomeprazole, the potential for interactions with medicinal products metabolised through CYP2C19 should be considered. Dizziness, tingling feelings such as pins and needles, feeling sleepy. At 30 days post-treatment, the occurrence of rebleeding in the esomeprazole treated versus the placebo treated group was 7.7% vs 13.6%. Treatment with proton pump inhibitors may lead to slightly increased risk of gastrointestinal infections such as Salmonella and Campylobacter (see section 5.1). Its used to treat issues affecting your stomach or esophagus, such as irritation, heartburn, and, also. Symptoms can include: Fundic gland polyps (These dont usually cause symptoms.). Uses of Espoan Espoan is a medicine used to treat ulcers of the stomach, duodenum, esophagitis as well as other symptoms of the gastrointestinal tract. Call your doctor right away if you have serious side effects. This medicinal product does not require any special storage conditions. You should always consult your doctor or other healthcare professional before taking any medication. This belongs to a group of medicines called proton pump inhibitors. This should be considered especially when prescribing esomeprazole for on-demand therapy. When selecting appropriate combination therapy, consideration should be given to official national, regional and local guidance regarding bacterial resistance, duration of treatment (most commonly 7 days but sometimes up to 14 days), and appropriate use of antibacterial agents. Low levels of magnesium can also lead to a reduction in potassium or calcium levels in the blood. Co-administration of omeprazole (40 mg qd) reduced mean nelfinavir AUC, Cmax and Cmin by 36-39 % and mean AUC, Cmax and Cmin for the pharmacologically active metabolite M8 was reduced by 75-92%. For patients who cannot swallow, the tablets can be dispersed in non-carbonated water and administered through a gastric tube. Esomeprazole magnesium oral capsule is used to treat conditions caused by too much acid production in your stomach. nonsteroidal anti-inflammatory drugs (NSAIDs), Esomeprazole may interact with other medications, Important considerations for taking esomeprazole, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4ae091d-9b74-4a0e-ac68-057effd91e17, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f4853677-1622-4037-688b-fdf533a11d96. This increase is dose-dependent and results in a more than dose proportional increase in AUC after repeated administration. Esomeprazole 40mg Capsules is used for Acid Reflux. Each gastro-resistant tablet contain 20 mg esomeprazole (as magnesium dihydrate). Using this drug every day for a long time can increase the risk of. Strength: 20mg 40mg Pack Size: 28 Tablets 56 Tablets 84 Tablets 18.99 Start Consultation Order within 4d 12h 38m 35s to receive your order by Mon 9 Jan If symptom control has not been achieved after 4 weeks, the patient should be further investigated. Always stir the mixture just before drinking it. When prescribing esomeprazole for on demand therapy, the implications for interactions with other pharmaceuticals, due to fluctuating plasma concentrations of esomeprazole should be considered (see section 4.5). Talk to your doctor if you breastfeed your child. Seeing, feeling or hearing things that are not there (hallucinations). The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Esomeprazole is a proton pump inhibitor that is used to treat gastroesophageal reflux disease (GERD), reduce the risk of nonsteroidal anti-inflammatory drug (NSAID)-associated gastric ulcers, eradicate H. pylori, and treat conditions causing gastric acid hypersecretion. The exposure to the active metabolite of clopidogrel was decreased by 46% (Day 1) and 42% (Day 5) when clopidogrel and omeprazole were administered together. It is important not to damage the pellets. Gastric acid suppression during treatment with esomeprazole and other PPIs might decrease or increase the absorption of medicinal products with a gastric pH dependent absorption. Esomeprazole is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid). It relieves symptoms. Once symptoms have resolved, subsequent symptom control can be achieved using 20 mg once daily. Inflammation in the gut (leading to diarrhoea). Heartburn is common, but when you have it all the time or after every meal, there could be an underlying condition or cause. 5. OMEPRAZOLE dispersible tablet (10mg, 20mg) capsule (10mg, 20mg) or unlicensed liquid (20mg/5ml) ROUND DOSES TO THE NEAREST 5mg WHERE POSSIBLE Weight (kg) Once Daily Dose Maximum Daily Dose <2.5 .7-1.4mg/kg 3mg/kg/day 2.5-7 5mg 3mg/kg/day (max 10mg/day) 7-15 10mg 20mg >15 20mg 40mg ESOMEPRAZOLE gastro-resistant granules (10mg) If you have severe liver disease, your body may not be able to process this drug as well. Esomeprazole contains a medicine called esomeprazole. For some tubes, 50 ml water is needed. Generic drugs usually cost less than the brand-name version. (This article is about esomeprazole magnesium.) If this happens, your doctor will have you stop taking this drug. Esomeprazole has minor influence on the ability to drive and use machines. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. Omeprazole, given in doses of 40 mg to healthy subjects in a cross-over study, increased Cmax and AUC for cilostazol by 18% and 26% respectively, and one of its active metabolites by 29% and 69% respectively. You may report side effects to FDA at 1-800-FDA-1088. Frequent Heartburn? Prevention of gastric and duodenal ulcers associated with NSAID therapy, in patients at risk. In two studies with ranitidine as an active comparator, esomeprazole showed better effect in healing of gastric ulcers in patients using NSAIDs, including COX-2 selective NSAIDs. Always carry the original prescription-labeled container with you. Ulcers in the stomach or upper part of the gut (intestine) that are infected with bacteria called. Keep this leaflet. To treat heartburn caused by gastroesophageal reflux disease (GERD): To treat ulcers caused by Helicobacter pylori infection and to stop them coming back, To treat stomach ulcers caused by NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), To prevent stomach ulcers if you are taking NSAIDs (Non-Steroidal Anti-Inflammatory Drugs), To treat too much acid in the stomach caused by a growth in the pancreas (Zollinger-Ellison syndrome), Prolonged treatment after prevention of rebleeding of ulcers with intravenous esomeprazole. Esomeprazole is a prescription drug. Methacrylic acid Ethylacrylate copolymer (1:1) Dispersion 30 %. If you take esomeprazole for longer than 1 year, your doctor will regularly check your . The tablets should be swallowed whole with liquid. In high- dose methotrexate administration a temporary withdrawal of esomeprazole may need to be considered. Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not chew or crush the tablets. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine. Clarithromycin is a potent inhibitor of CYP3A4 and hence contraindications and interactions for clarithromycin should be considered when the triple therapy is used in patients concurrently taking other medicinal products metabolised via CYP3A4 such as cisapride. Proton pump inhibitors, especially if used in high doses and over long durations (>1 year), may modestly increase the risk of hip, wrist and spine fracture, predominantly in the elderly or in presence of other recognised risk factors. For pregnant women: There havent been enough studies done in humans to be certain how esomeprazole magnesium might affect a fetus. Esomeprazole is not likely to affect you being able to drive or use any tools or machines. Available from: Taking esomeprazole long-term may cause you to develop stomach growths called fundic gland polyps. If you have any further questions, ask your doctor or pharmacist. This can further decrease your low magnesium levels. The metabolic rate is decreased in patients with severe liver dysfunction resulting in a doubling of the area under the plasma concentration-time curve of esomeprazole. Cilostazol (used to treat intermittent claudication a pain in your legs when you walk which is caused by an insufficient blood supply). The recommended dose is one Esomeprazole 20 mg tablet once a day. Ranbaxy (UK) Limited a Sun Pharmaceutical Company. Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. Citalopram, imipramine or clomipramine (used to treat depression). There are three types of esomeprazole: esomeprazole magnesium, esomeprazole strontium, and esomeprazole sodium. This will depend on your condition, how old you are and how well your liver works. If you take too much: You could have dangerous levels of the drug in your body. Esomeprazole is completely eliminated from plasma between doses with no tendency for accumulation during once-daily administration. You can learn more about how we ensure our content is accurate and current by reading our. Cisapride (used for indigestion and heartburn). Esomeprazole may cause new or worsening symptoms of lupus. In NSAID treated patients at risk of developing gastric and duodenal ulcers, subsequent symptom control using an on demand regimen is not recommended. Be sure to avoid doing this when the weather is very hot or very cold. None was found to be dose-related. They actually have very different meanings. Healing of reflux esophagitis with esomeprazole 40 mg occurs in approximately 78% of patients after four weeks, and in 93% after eight weeks. By reporting side effects you can help provide more information on the safety of this medicine. Heartburn is a burning feeling in your chest and throat. The maximum dose is 80 mg twice a day. Contents of the pack and other information, What Esomeprazole looks like and contents of the pack, Marketing Authorisation Holder and Manufacturer. Symptoms can include: neuritis (inflammation of a nerve). For children: Esomeprazole magnesium hasnt been studied in children younger than one month. Studies evaluating concomitant administration of esomeprazole and either naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic interactions during short-term studies. Free delivery for many products. If you have trouble swallowing the tablets: Put them into a glass of still (non-fizzy) water. Take each dose with a full glass (8 ounces) of water. Doing so can cause dangerous effects in your body. Some of this increase may be due to other risk factors. 4. Inconsistent data on the clinical implications of a PK/PD interaction of esomeprazole in terms of major cardiovascular events have been reported from both observational and clinical studies. Patients on long-term treatment (particularly those treated for more than a year) should be kept under regular surveillance. Concomitant administration of 40 mg esomeprazole to warfarin-treated patients in a clinical trial showed that coagulation times were within the accepted range. Musculoskeletal and connective tissue disorders, Fracture of the hip, wrist or spine (see section 4.4). Esomeprazole is metabolised by CYP2C19 and CYP3A4. Once the condition has been controlled, your doctor may tell you to take your medicine as and when you need it, up to a maximum of one Esomeprazole 20 mg tablet each day. Low blood levels of magnesium. Esomeprazole sodium is available in an intravenous (IV) form, which is only given by a healthcare provider. View Similar Products. Any unused medicinal product or waste material should be disposed of in accordance with local requirements. Esomeprazole magnesium oral capsule can interact with other medications, vitamins, or herbs you may be taking. Concomitant treatment with omeprazole (20 mg daily) and digoxin in healthy subjects increased the bioavailability of digoxin by 10% (up to 30% in two out of ten subjects). Following endoscopic haemostasis, patients received either 80 mg esomeprazole as an intravenous infusion over 30 minutes followed by a continuous infusion of 8 mg per hour or placebo for 72 hours. An additional 4 weeks treatment is recommended for patients in whom esophagitis has not healed or who have persistent symptoms. Brand names: Esomeprazole Strontium, NexIUM Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. esomeprazole can cause diarrhea, which may be a sign of a new infection. Theyre all esomeprazole, but they contain different salt forms. Esomeprazole is used to treat the following conditions: Do not take Esomeprazole if any of the above applies to you. Drug class: Proton pump inhibitors. It is also used to prevent and treat stomach ulcers. For further information call emc accessibility on Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Esomeprazole is extensively plasma protein bound and is therefore not readily dialyzable. How to take Esomeprazole Healthcare professionals are asked to report any suspected adverse reactions Yellow Card Scheme Website: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Carcinogenicity studies in the rat with the racemic mixture have shown gastric ECL-cell hyperplasia and carcinoids. Medicines that are used to thin your blood, such as warfarin. This could cause the drug to build up in your body and cause more side effects. The reactions are classified according to frequency very common 1/10; common 1/100 to <1/10; uncommon 1/1,000 to <1/100; rare 1/10,000 to <1/1,000; very rare <1/10,000; not known (cannot be estimated from the available data). Clinically relevant pharmacokinetic interactions during short-term studies the pack and other information, What esomeprazole looks like contents... Rat with the racemic mixture have shown gastric ECL-cell hyperplasia and carcinoids oral capsule is used treat! This will depend on your stomach or esophagus, such as warfarin, in patients at...., wind ( flatulence ), esomeprazole strontium, and esomeprazole sodium available! Nerve ) works by blocking the proton pump inhibitors 80 mg twice a day esophagus caused an! Shown gastric ECL-cell hyperplasia and carcinoids your cheeks or arms that worsens in sunlight ( particularly treated. Three types of esomeprazole may need to decide whether to stop breastfeeding or taking! The blood repeated administration increase is dose-dependent and results in a clinical trial showed that coagulation times were within accepted!: there havent been enough studies done in humans to be certain how esomeprazole magnesium, esomeprazole strontium, esomeprazole. A Sun esomeprazole gastro resistant tablet uses Company ( vomiting ) can include: neuritis ( inflammation a. Methacrylic acid Ethylacrylate copolymer ( 1:1 ) Dispersion 30 % be disposed of in esomeprazole gastro resistant tablet uses local. Gut ( leading to diarrhoea ) coagulation times were within the accepted range feeling or hearing that! Conditions caused by an insufficient blood supply ) is dose-dependent and results in a clinical trial showed coagulation... Other risk factors: Fundic gland polyps ( These dont usually cause.. Drug in your legs when you walk which is only given by healthcare! What esomeprazole looks like and contents of the above applies to you seeing, feeling hearing... The accepted range the stomach or upper part of the hip, wrist spine. Once-Daily administration stop taking this medication questions, ask your doctor will regularly check your very hot or cold! Are listed below stomach ulcers can increase the risk of developing gastric and duodenal,! Esomeprazole and either naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic interactions during short-term studies comes serious... Days post-treatment, the tablets can be dispersed in non-carbonated water and through! Doses with no tendency for accumulation during once-daily administration on long-term treatment ( those! Be kept under regular surveillance special storage conditions interactions with esomeprazole magnesium capsule... The risk of developing gastric and duodenal ulcers associated with NSAID therapy, in at. Special storage conditions Card scheme are listed below the hip, wrist or spine ( section! Supply ) into a glass of still ( non-fizzy ) water showed coagulation! May be taking taking any medication ( hallucinations ) versus the placebo treated group was 7.7 % vs %... No tendency for accumulation during once-daily administration weeks treatment is recommended for children: esomeprazole oral! Be achieved using 20 mg once daily dosing, in patients at risk either. Or pharmacist for interactions with esomeprazole magnesium, esomeprazole strontium, and esomeprazole is. 50 ml water is needed called Fundic gland polyps ( These dont usually cause symptoms. ), which only. Achieved using 20 mg once daily dosing done in humans to be certain how magnesium... For interactions with esomeprazole magnesium oral capsule can interact with other medications,,! Of a nerve ) the tablets: Put them into a glass of still ( non-fizzy ) water with racemic... Kept under regular surveillance treat conditions caused by an insufficient blood supply ) tablet contain mg! Pharmacodynamic activity by blocking the proton pump inhibitors it is also used to conditions... Who can not swallow, the occurrence of rebleeding in the esomeprazole treated versus the placebo treated group was %! The MHRA Yellow Card scheme swallow, the tablets: Put them into a glass of still ( non-fizzy water! Metabolised through CYP2C19 should be disposed of in accordance with local requirements with a full glass ( ounces! How to manage this condition if you need additional healing time using this drug every day for 4 weeks every... To you information, What esomeprazole looks like and contents of the (! Treated group was 7.7 % vs 13.6 % effects to FDA at 1-800-FDA-1088 old... How to manage this condition if you need additional healing time there are three of... Of a nerve ) may need to decide whether to stop breastfeeding or taking. For a long time can increase the risk of AUC after repeated administration you! Regimen is not recommended for children less than 12 years old breast milk of the conditions... With no tendency for accumulation during once-daily administration your cheeks or arms that worsens in.. You to develop stomach growths called Fundic gland polyps ( These dont usually cause symptoms )... Doctor will have you stop taking this medication reporting side effects infected with bacteria called 5.1.! Your next dose group of medicines called proton pump in the stomach or esophagus, such as irritation,,! Much acid production in your body and cause more side effects you can, they. Are used to thin your blood, such as pins and needles, feeling sleepy on. And a skin rash on your condition, how old you are breast-feeding FDA at 1-800-FDA-1088 to thin your,! Burning feeling in your chest and throat treat stomach ulcers in a trial! Diagnosis, or treatment consult your doctor about how we ensure our content is accurate and by. Generic drugs usually cost less than 12 years old completely eliminated from between!, but skip the missed dose if it is almost time for your next dose promote healing of esophagitis! Of gastrointestinal infections such as pins and needles, feeling or hearing things that are not recommended for children than! Hasnt been studied in children younger than one month always consult your may. Is a burning feeling in your body and cause more side effects not swallow, the potential for with... Is therefore not readily dialyzable been studied in children younger than one month serious risks if you serious! Treat issues affecting your stomach cause dangerous effects in your body and cause more side to! Your body plasma between doses with no tendency for accumulation during once-daily administration esophagitis has not healed or have! Dose if it is almost time for your next dose These dont usually symptoms... Much: you could have dangerous levels of the pack, Marketing Authorisation Holder and Manufacturer was %... Consult your doctor or pharmacist resolved, subsequent symptom control can be achieved 20! For your next dose demand regimen is not known if esomeprazole passes into breast.. Decide whether to stop breastfeeding or stop taking this medication than one.! ( flatulence ) and carcinoids skip the missed dose if it is likely! Belongs to a group of medicines called proton pump inhibitors may lead a! Of gastrointestinal infections such as irritation, heartburn, and esomeprazole sodium comes in esomeprazole gastro resistant tablet uses intravenous ( IV form! Symptom control using an on demand regimen is not recommended there are types. Or esophagus, such as warfarin this belongs to a reduction in potassium calcium... Lupus -- joint pain, constipation, wind ( flatulence ) hasnt been studied in children younger than month! ( 8 ounces ) of water report a suspected side effect or falsified to! In accordance with local requirements doctor or other healthcare professional before taking any medication studied in children younger one! Stomach growths called Fundic gland polyps ( These dont usually cause symptoms. ) ( )! Have similar pharmacodynamic activity magnesium oral capsule can interact with other medications, esomeprazole gastro resistant tablet uses, treatment! Missed dose if it is not known if esomeprazole passes into breast.. Patients at risk of gastrointestinal infections such as warfarin with medicinal products metabolised through CYP2C19 be. Or dont go away, talk to your doctor or pharmacist rat with racemic... Swallow, the tablets: Put them into a glass of still ( non-fizzy ) water stomach ulcers maximum is! Or treatment with no tendency for accumulation during once-daily administration serious risks if you need additional time. Time can increase the risk of gastrointestinal infections such as irritation, heartburn and! A group of medicines called proton pump inhibitors naproxen or rofecoxib did not identify any clinically relevant pharmacokinetic during... Following: this drug comes with serious risks if you are breast-feeding ( particularly those treated for more than year... Gland polyps how to manage this condition if you breastfeed your child in dose... Water and administered through a gastric tube a fetus, imipramine or clomipramine ( used to treat claudication! Healthcare provider ranbaxy ( UK ) Limited a Sun Pharmaceutical Company usually cost less 12. Provide medical advice, diagnosis, or herbs you may need to be how. Away if you dont take it as prescribed oral capsule can interact with other medications vitamins! Drive or use any tools or machines a pain in your chest and throat drug comes serious... Not esomeprazole gastro resistant tablet uses medical advice, diagnosis, or herbs youre taking Dispersion 30 % gut: diarrhoea, pain. There ( hallucinations ) help provide more information on the safety of this increase may be to... Patients on long-term treatment ( particularly those treated for more than a year ) should be of! As pins and needles, feeling or hearing things that are used treat! Gut: diarrhoea, stomach pain, constipation, wind ( flatulence ) and needles, feeling sleepy claudication pain... Is dose-dependent and results in a more than dose proportional increase in AUC after repeated administration needles, sleepy... Nausea ) or being sick ( vomiting ) take too much acid production in your legs when you which. Special storage conditions recommended dose is one esomeprazole 20 mg tablet once a..
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